Mariateresa Vaccaro

DC11

I have always been deeply fascinated by metabolic pathways—specifically how human metabolism influences the biotransformation of drugs and food bioactives, and how these newly generated molecules impact health. Within the BioTransform network, I am excited to work in a highly collaborative environment alongside the other DCs, combining our efforts to investigate olive oil and bilberry metabolites against widespread diseases affecting our society.

DC11 Open Position: Synthesis of potentially bioactive metabolites for chemical structure revision, analytical quantification and bioactivity studies​

Supervisor:Dr. Gints Smits

Co-Supervisors: Prof. Maria Halabalaki (NKUA), Dr. Dimitrios Michailidis (PharmaGnose)

Secondments This project is carried out in strong collaboration with the institutions listed below:

  • Department of Pharmacy, National and Kapodistrian University of Athens (NKUA), Greece
  • Institute of Pharmaceutical Sciences, Pharmacognosy, University of Graz, Austria
  • PharmaGnose Biotechnologies, Athens, Greece
Project description

While the role of the gut microbiota is already confirmed as pivotal in food and drug metabolism, the specific biological influence of these metabolic pathways—particularly those involving olive oil and bilberries—remains largely unexplored. The aim of my project, DC11, is to bridge the gap between the molecules we ingest and those that actually exert a therapeutic effect on our health. To achieve this, I will use state-of-the-art synthetic methods to generate high-purity analytical standards. These pure molecules will be crucial for the structural elucidation of food metabolites, serving as indispensable references for both bioanalytical quantification (in clinical samples like plasma, urine, and feces) and subsequent biological assays across the network.

Professional background

I graduated with a Single-Cycle Master’s degree in Chemistry and Pharmaceutical Technologies from the University of Bologna, and completed my Master’s thesis research at the Universidad Complutense de Madrid (Spain). Through these experiences, I developed a strong passion for organic synthesis and structural elucidation, both of which are central to the DC11 project.