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Romit Kumar Subba

DC2
Google

I am motivated to explore how natural compounds are differentially transformed in the human body and how this influences metabolic health. This BioTransform project gives me the opportunity to study such variability using advanced analytical methods.

DC2: Tracking differences in gastrointestinal metabolism of olive oil biophenols between healthy/normal weight and prediabetic/obese individuals through the in vitro gastrointestinal simulation model GIDM-colon

Supervisor: Prof. Nina Hermans

Co-Supervisors: Prof. Paul Cotter (Teagasc), Dr. Dimitrios Michailidis (PharmaGnose)

Secondments This project is carried out in strong collaboration with the institutions listed below:

  • Food Biosciences Department, Agriculture and Food Development Authority (Teagasc), Cork, Ireland
  • Department of Pharmacy, National and Kapodistrian University of Athens (NKUA), Greece
  • PharmaGnose Biotechnologies, Athens, Greece
Project description

This project aims to investigate the metabolism of olive biophenols and how it differs between healthy, normal weight individuals and those with prediabetes and obesity across Central and South European cohorts. For this, we will be using advanced metabolomics approaches after biotransformation studies of olive biophenols in the in vitro gastrointestinal simulation model GIDM-colon inoculated with fecal cultures obtained from parallel clinical studies to characterize gut-derived metabolite profiles in these populations. The findings are expected to reveal variability in olive biophenol metabolism and provide insights into their role in metabolic health. I am particularly interested in integrating clinical data with metabolomics to understand how different physiological states influence the processing of natural compounds.

Professional background

I completed my Bachelor of Pharmacy in Nepal, and my Master of Pharmacy in South Korea. My early research focused on the phytochemistry and in vitro bioactivity of barley grass, which sparked my interest in bioactive natural products. During my master’s research, I investigated how disease states and endogenous molecules such as bile acids influence drug transporters and metabolizing enzymes, and how these changes affect the exposure of drugs and their metabolites. Through these experiences, I developed a strong interest in metabolism-driven variability and gained practical exposure to analytical and metabolomics-oriented research.